What is the 4D Nucleome Program Youtube screenshot
What is the 4D Nucleome Program?
Watch this video on YouTube to learn how 4DN aims to improve public health!
Reporting and reproducibility in microscopy
The Nature Methods FOCUS issue on Reporting and reproducibility in microscopy features a series of papers that emerged from the work of the 4D Nucleome Imaging Working group in collaboration with BioImaging North America, QUAREP-LiMi, and Global Bioimaging, offering guidelines and tools for improving the tracking and reporting of microscopy metadata with an emphasis on reproducibility and data re-use. Following up on this work, Nature Methods featured two editorials describing the importance of Imaging standards to ease reproducibility and the everyday and The making microscope camera standards by bringing together the imaging community with microscope camera manufacturers.
The 4D Nucleome project Nature article Figure 1
The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Validated experimental technologies will be combined with biophysical approaches to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells. The 4D nucleome project. Nature 549, pages 219–226
Tutorial for 4DN new members
Tutorial for 4DN new members
Welcome to 4DN! Watch this video on YouTube to learn how to use 4DN tools and services!
Nature 3D genome paper collection figure
The 3D genome
This collection includes recent articles from across the Nature group of journals and showcases both the latest advances in the methodologies used to study genome organization, and our recent understanding of how genome organization and nuclear architecture regulate gene expression, cell fate and cell function in physiology and disease. The content of this collection has been chosen by the editors of Nature Reviews Molecular Cell Biology.