4DN Phase II Funded Research Announcements
The first phase of the 4DN program was very successful, but there is still a need to deliver data and tools to the broader biomedical research community to address the role of nuclear organization in health and disease. A second stage of funding for the 4DN program is beginning and funded research groups have all been announced.
The 3D genome
This collection includes recent articles from across the Nature group of journals and showcases both the latest advances in the methodologies used to study genome organization, and our recent understanding of how genome organization and nuclear architecture regulate gene expression, cell fate and cell function in physiology and disease. The content of this collection has been chosen by the editors of Nature Reviews Molecular Cell Biology.
What is the 4D Nucleome Program?
Watch this video on Youtube to learn how 4DN aims to improve public health!
The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Validated experimental technologies will be combined with biophysical approaches to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells. The 4D nucleome project. Nature 549, pages 219–226