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What is the 4D Nucleome Program?
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Reporting and reproducibility in microscopy
The Nature Methods FOCUS issue on Reporting and reproducibility in microscopy features a series of papers that emerged from the work of the 4D Nucleome Imaging Working group in collaboration with BioImaging North America, QUAREP-LiMi, and Global Bioimaging, offering guidelines and tools for improving the tracking and reporting of microscopy metadata with an emphasis on reproducibility and data re-use. Following up on this work, Nature Methods featured two editorials describing the importance of Imaging standards to ease reproducibility and the everyday and The making microscope camera standards by bringing together the imaging community with microscope camera manufacturers.
The 4D Nucleome Network aims to develop and apply approaches to map the structure and
dynamics of the human and mouse genomes in space and time with the goal of gaining deeper
mechanistic insights into how the nucleus is organized and functions. The project will
develop
and benchmark experimental and computational approaches for measuring genome conformation
and
nuclear organization, and investigate how these contribute to gene regulation and other
genome
functions. Validated experimental technologies will be combined with biophysical approaches
to
generate quantitative models of spatial genome organization in different biological states,
both in cell populations and in single cells. The 4D nucleome project.
Nature
549, pages 219–226
Tutorial for 4DN new members
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The 3D genome
This collection includes recent articles from across the Nature group of journals and showcases both the latest advances in the methodologies used to study genome organization, and our recent understanding of how genome organization and nuclear architecture regulate gene expression, cell fate and cell function in physiology and disease. The content of this collection has been chosen by the editors of Nature Reviews Molecular Cell Biology.
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